The volume contains a bonus chapter introducing a section hosted by Junko. eventually decides to go to Tokyo to follow her own dream of being a rock star. Ren later leaves the group in order to join an up and coming band in Tokyo called Trapnest. She talks about how she and bassist Ren Honjo first met and later became lovers. Nana Osaki is the lead singer for a rock band called Blast. wants to join them but must stay to earn some money before making that dream come true. However, when Junko and Kyosuke announce they are moving to Tokyo with Shoji soon to follow, Nana K. at first wants to just be friends with Shoji, but later gives in and they become lovers. She and her friend Junko enroll in a local art school college where they meet Kyosuke Takakura and Shoji Endo. Nana Komatsu is a high school graduate who has had a number of crushes on older men, including being a mistress for a salaryman. The stories follow each Nana's life before they met each other: It is also licensed in Germany by Egmont Manga & Anime, in Italy and Mexico by Panini Comics, in France by Éditions Delcourt, in Taiwan by Sharp Point Press, in South Korea by Haksan Publishing, in Spain by Planeta DeAgostini, in Brazil by Editora JBC, in Argentina by Editorial Ivrea, and in Thailand by Bongkoch Publishing. Madman Entertainment distributes the series in New Zealand and Australia.

The series continued publication in book form, with all 21 volumes released as of July 6, 2010. It was serialized in Viz's manga anthology Shojo Beat, from July 2005 to August 2007. Nana is licensed for English-language release in North America by Viz Media. The chapters have been collected and published in 21 tankōbon volumes in Japan by Shueisha. This is the first manga she has published since her 2009 illness. Yazawa published a two-page chapter of 'Junko's Room', a side story about a friend of one of the two main characters, in the March 2013 issue of Cookie.

Yazawa returned from hospital in early April 2010, though had not specified when or if she will resume the manga. Nana premiered in the Japanese manga magazine Cookie in 2000 where it ran until June 2009, when the series was put on hiatus because of Yazawa's illness. The chapters of Nana are written and illustrated by Ai Yazawa. The cover of the first Nana volume as published by Shueisha in Japan on May 15, 2000

Nana vol 1